waters micromass platform lcz mass spectrometer (Micromass UK Limited)
90
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Micromass UK Limited
waters micromass platform lcz mass spectrometer
Waters Micromass Platform Lcz Mass Spectrometer, supplied by Micromass UK Limited, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/lcz+mass+spectrometer/waters+micromass+platform+lcz+system/pm40319530-40-11-11
Average 90 stars, based on 1 article reviews
Waters Micromass Platform Lcz Mass Spectrometer, supplied by Micromass UK Limited, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/lcz+mass+spectrometer/waters+micromass+platform+lcz+system/pm40319530-40-11-11
Average 90 stars, based on 1 article reviews
waters micromass platform lcz mass spectrometer - by Bioz Stars,
2026-10
90/100 stars
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Liquid Chromatography with Mass Spectroscopy:Article Title: ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis. Article Snippet: 1H spectra were obtained using Bruker 400 MHz NMR spectrometers. .. LC-MS data were collected using a Article Title: Preparation of tritium-labeled PF-622, a novel fatty acid amide hydrolase inhibitor. Article Snippet: In order to make a detailed characterization of the mechanism of inhibition and selectivity of a novel fatty acid amide hydrolase inhibitor PF-622, three tritium isotopomers were prepared.. [ 3 H]PF-622a labeled at the piperazine ring B and [ 3 H]PF-622b labeled at both the ring B and phenyl ring A were synthesized via catalytic H(hydrogen)-T(tritium) exchange, utilizing 1 equiv. and excess of Crabtree’s catalyst, respectively.. The preparation of [ 3 H]PF-622c labeled only at the phenyl ring A was achieved via tritiodebromination of the bromide precursor, using Pd(PPh3)4 as a catalyst. Article Title: A modified approach to C-14-labeled 2-(3,4-difluorophenoxy)-5-fluoronicotinic acid and other halogen-substituted analogs Article Snippet: A modified approach to a carbon-14-labeled pyridine ring system was developed based on the electrocyclic ring-closure of 1,4,4-trisubstituted butadiene.. The new method was applied to prepare 2-(3,4-difluorophenoxy)-5-fluoro-[2-C] nicotinic acid and other halogen-substituted analogs.. The targeted compound was isolated with a radiochemical purity of 498% and a specific activity of 53 mCi/mmol from four radiochemical steps, starting from ethyl [1-C] cyanoacetate in an overall radiochemical yield of 39%. Article Title: Cyanoquinoline derivatives, their preparation, their use, and medicaments comprising them Article Snippet: .. LC-MS Method B Data were recorded in analogy to method A on an HPLC instrument of the HP1100 series (Agilent) coupled to a Mass Spectrometry:Article Title: ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis. Article Snippet: 1H spectra were obtained using Bruker 400 MHz NMR spectrometers. .. LC-MS data were collected using a Article Title: Heterocyclic compounds Article Snippet: .. Mass spectra were recorded using an HPLC-MS system employing a HP-1100 HPLC and a Article Title: Facile syntheses of isotope-labeled chiral octahydroindole-2-carboxylic acid and its N-methyl analog Article Snippet: We have synthesized deuterium and carbon-14 labeled enantiomerically pure octahydroindole-2-carboxylic acid (PD0140417), N-methyl octahydroindole-2-carboxylic acid (PD0348183) and their racemic analogs (PD0108405 and PD0338055).. [ring-U-C]PD0140417 was prepared from [ring-U-C]benzoic acid in a seven-step synthesis in 6.2% overall radiochemical yield.. [C]PD0348183 was prepared from [C]BaCO3 in a five-step synthesis in 16% radiochemical yield. Article Title: Complex Drug Interactions of HIV Protease Inhibitors 1: Inactivation, Induction, and Inhibition of Cytochrome P450 3A by Ritonavir or Nelfinavir Article Snippet: MDZ, 1′-OH-MDZ, and stable labeled (D4) analogs [internal standard (IS) for MDZ and 1′OH-MDZ analysis] were purchased from Cerilliant Corporation (Round Rock, TX). .. Relative quantification of 1′-OH-MDZ formation and depletion of RTV or NFV from HLM and SCHH experiments was performed by liquid chromatography-mass spectrometry using a Micromass Article Title: Preparation of tritium-labeled PF-622, a novel fatty acid amide hydrolase inhibitor. Article Snippet: In order to make a detailed characterization of the mechanism of inhibition and selectivity of a novel fatty acid amide hydrolase inhibitor PF-622, three tritium isotopomers were prepared.. [ 3 H]PF-622a labeled at the piperazine ring B and [ 3 H]PF-622b labeled at both the ring B and phenyl ring A were synthesized via catalytic H(hydrogen)-T(tritium) exchange, utilizing 1 equiv. and excess of Crabtree’s catalyst, respectively.. The preparation of [ 3 H]PF-622c labeled only at the phenyl ring A was achieved via tritiodebromination of the bromide precursor, using Pd(PPh3)4 as a catalyst. Article Title: A modified approach to C-14-labeled 2-(3,4-difluorophenoxy)-5-fluoronicotinic acid and other halogen-substituted analogs Article Snippet: A modified approach to a carbon-14-labeled pyridine ring system was developed based on the electrocyclic ring-closure of 1,4,4-trisubstituted butadiene.. The new method was applied to prepare 2-(3,4-difluorophenoxy)-5-fluoro-[2-C] nicotinic acid and other halogen-substituted analogs.. The targeted compound was isolated with a radiochemical purity of 498% and a specific activity of 53 mCi/mmol from four radiochemical steps, starting from ethyl [1-C] cyanoacetate in an overall radiochemical yield of 39%. Article Title: Cyanoquinoline derivatives, their preparation, their use, and medicaments comprising them Article Snippet: .. LC-MS Method B Data were recorded in analogy to method A on an HPLC instrument of the HP1100 series (Agilent) coupled to a High Performance Liquid Chromatography:Article Title: Heterocyclic compounds Article Snippet: .. Mass spectra were recorded using an HPLC-MS system employing a HP-1100 HPLC and a Article Title: Cyanoquinoline derivatives, their preparation, their use, and medicaments comprising them Article Snippet: .. LC-MS Method B Data were recorded in analogy to method A on an HPLC instrument of the HP1100 series (Agilent) coupled to a Injection:Article Title: Facile syntheses of isotope-labeled chiral octahydroindole-2-carboxylic acid and its N-methyl analog Article Snippet: We have synthesized deuterium and carbon-14 labeled enantiomerically pure octahydroindole-2-carboxylic acid (PD0140417), N-methyl octahydroindole-2-carboxylic acid (PD0348183) and their racemic analogs (PD0108405 and PD0338055).. [ring-U-C]PD0140417 was prepared from [ring-U-C]benzoic acid in a seven-step synthesis in 6.2% overall radiochemical yield.. [C]PD0348183 was prepared from [C]BaCO3 in a five-step synthesis in 16% radiochemical yield. Article Title: Preparation of tritium-labeled PF-622, a novel fatty acid amide hydrolase inhibitor. Article Snippet: In order to make a detailed characterization of the mechanism of inhibition and selectivity of a novel fatty acid amide hydrolase inhibitor PF-622, three tritium isotopomers were prepared.. [ 3 H]PF-622a labeled at the piperazine ring B and [ 3 H]PF-622b labeled at both the ring B and phenyl ring A were synthesized via catalytic H(hydrogen)-T(tritium) exchange, utilizing 1 equiv. and excess of Crabtree’s catalyst, respectively.. The preparation of [ 3 H]PF-622c labeled only at the phenyl ring A was achieved via tritiodebromination of the bromide precursor, using Pd(PPh3)4 as a catalyst. Article Title: A modified approach to C-14-labeled 2-(3,4-difluorophenoxy)-5-fluoronicotinic acid and other halogen-substituted analogs Article Snippet: A modified approach to a carbon-14-labeled pyridine ring system was developed based on the electrocyclic ring-closure of 1,4,4-trisubstituted butadiene.. The new method was applied to prepare 2-(3,4-difluorophenoxy)-5-fluoro-[2-C] nicotinic acid and other halogen-substituted analogs.. The targeted compound was isolated with a radiochemical purity of 498% and a specific activity of 53 mCi/mmol from four radiochemical steps, starting from ethyl [1-C] cyanoacetate in an overall radiochemical yield of 39%. Quantitative Proteomics:Article Title: Complex Drug Interactions of HIV Protease Inhibitors 1: Inactivation, Induction, and Inhibition of Cytochrome P450 3A by Ritonavir or Nelfinavir Article Snippet: MDZ, 1′-OH-MDZ, and stable labeled (D4) analogs [internal standard (IS) for MDZ and 1′OH-MDZ analysis] were purchased from Cerilliant Corporation (Round Rock, TX). .. Relative quantification of 1′-OH-MDZ formation and depletion of RTV or NFV from HLM and SCHH experiments was performed by liquid chromatography-mass spectrometry using a Micromass Chromatography:Article Title: Complex Drug Interactions of HIV Protease Inhibitors 1: Inactivation, Induction, and Inhibition of Cytochrome P450 3A by Ritonavir or Nelfinavir Article Snippet: MDZ, 1′-OH-MDZ, and stable labeled (D4) analogs [internal standard (IS) for MDZ and 1′OH-MDZ analysis] were purchased from Cerilliant Corporation (Round Rock, TX). .. Relative quantification of 1′-OH-MDZ formation and depletion of RTV or NFV from HLM and SCHH experiments was performed by liquid chromatography-mass spectrometry using a Micromass other:Article Title: Syntheses of dual-radioisotope-labeled CP-I, a GABAA receptor partial agonist Article Snippet: CP-I is a potent subtype-selective GABAA receptor partial agonist.. Owing to its significant metabolic cleavage at C8 observed in preliminary biotransformation studies with non-radiolabeled CP-I, the syntheses of CP-I labeled at the right or left hand side with C or labeled with 3H at the right hand side were required.. The two compounds labeled with C at the left or right hand side were synthesized in 2 and 5 radio-synthetic steps using [C]2-chloroacetyl chloride and [C]NaCN as starting radiolabeled materials, respectively. |